Deep Dive
YRMV : Your Results May Vary
1800 It was believed that BAD SMELLS caused disease. It was obvious; in poor districts, the air was foul and the death rate high. In the prosperous suburbs, no smells – therefore less disease. 60% of children died before the age of five.
1847 Ignaz Philipp Semmelweis "savior of mothers" proposed the practice of washing hands in obstetrical clinics.
1900 The leading causes of death were pneumonia, tuberculosis, diarrhea and enteritis. 40% of children died before the age of five
1950 The top 10 causes of death were, heart disease, cancer, stroke, accidents, influenza/pneumonia, tuberculosis, arteriosclerosis, kidney disease, and diabetes. 22% of children died before the age of five
2000 The leading causes of death were tobacco, poor diet and physical inactivity, alcohol consumption. Actual causes of death were microbial agents, toxic agents, motor vehicle crashes, firearms, sexual behaviors, and illicit use of drugs.
2015 4.5% of children died before the age of five
2023 Viruses, bacteria, fungi and parasites.
Paradigm shifts: Anatomy - Genetics - Epi-Genetics - Mitochondria
Did you know that you get all of your mitchondria
from your mother?
cell energy slaves
Mitochondrial biology and alterations in function were first linked to cancer in the 1920s with the discovery of the Warburg effect. The utilization of aerobic glycolysis in ATP synthesis was the first of many observations of metabolic reprogramming in cancer leading to the Hallmarks of Cancer in 2010.
Mitochondria are the energy slaves of the cell. Tesla 4680s batteries.
Mitochondria are surrounded by two membranes, and have their own genome (DNA) separate from the cell.
Mitochondrial DNA (mtDNA) has many special features such as a high copy number, maternal inheritance, and a high mutation rate.
Mitochondria divide independently of the cell in which they reside. Need more performance? Add more 4680 batteries.
Some of these features are holdovers from the ancient ancestors of mitochondria. ICE AGE Engines!
Mitochondria are involved in signaling between cells and cell death - apoptosis
"Studies have shown that mitochondria play an important role in statin-induced myopathies (1989 Merck Patents). In this review, we aim to report the mechanisms of action of statins on mitochondrial function. Results have shown that statins have several effects on mitochondria including reduction of coenzyme Q10 level, inhibition of respiratory chain complexes, induction of mitochondrial apoptosis, dysregulation of Ca2+ metabolism, and carnitine palmitoyltransferase-2 expression. The use of statins has been associated with the onset of additional pathological conditions like diabetes and dementia as a result of interference with mitochondrial pathways by various mechanisms, such as reduction in mitochondrial oxidative phosphorylation, increase in oxidative stress, decrease in uncoupling protein 3 concentration, and interference in amyloid-β metabolism."
- Journal of Cachexia, Sarcopenia and Muscle; Effects of statins on mitochondrial pathways; 29 January 2021
Chemical energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP). This metabolic biochemistry can occur through Aerobic Glycolysis (carbohydrates and fats are only burned in the presence of oxygen, this pathway requires oxygen to produce ATP) or Anaerobic Glycolysis (uses the energy contained in glucose for the formation of ATP and does not require oxygen).
All healthy cells can use either Aerobic Glycolysis or Anaerobic Glycolysis to create ATP but All Cancer Cells can only use Anaerobic Glycolysis, this is called the Warburg effect. Glucose is found in carbohydrates and sugars. But not in fats. Some conditions may apply.
Starving Cancer
Fasting and high fat diets restrict the glucose found in carbohydrates and sugars inhibiting Anaerobic Glycolysis and the ability of the cancer cell mitochondria to produce ATP creating stress and pushing the cell towards apoptosis, which is then brought on by the pulse of radiation treatment and flood of chemotherapy provided during standard lung cancer treatment.
Every cell in our body needs energy 100% of the time or it dies. Healthy cells are able to withstand the stress being placed on the cancer cells because our bodies have evolved to withstand starvation by withdrawing energy savings from our fat cells and muscle. Our healthy cells can do this,